LIVRO -“The roles of various Enzymes implicated in Atherosclerosis”- A contemporary study… (English Edition) PDF Dr. Hakim Saboowala

A prime cause of mortality across the developed societies- Atherosclerosis, was targeted by diverse therapeutic strategies. Many enzymes are associated with atherosclerosis, either in the main stream of lipid biosynthesis and transport or in the collateral and intertwined pathways of oxidative stress, inflammation, vascular remodeling or chromatin stability and are therefore reviewed in this booklet. Enzyme exploration led to important developments. At the beginning, there were the statins, derived as inhibitors of hydroxy-methyl-glutaryl CoA (HMG-CoA) reductase, currently used widely to decrease lipid levels. At the other end, the inhibitors of the recently discovered proprotein convertase subtilisin/kexin type 9 (PCSK9) are awaiting the validation in clinical trials with great hopes for the future. In between, one can find some palliatives, as aspirin, an inhibitor of cyclooxygenase (COX), but also many invalidated candidates. An attempt has been made in this booklet to include the Classical pharmacological data and newer approaches, like genetic knockouts in murine atherosclerosis models, in order to appreciate the involvement of a particular enzyme in atherogenesis. However, the pursuit of an efficacious drug has been long and, in many cases, disappointing. …..Dr.H.K.Saboowala.